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Reaching and maintaining a healthy weight is extremely important for overall health and well-being.  However, it has been a formidable challenge for many people to manage weight.  After all, the majority of American adults are overweight or obese -- nearly 75% of men and more than 60% women, based on a 2013 study published in The Lancet.

Extensive research has shown that obesity is a chronic inflammatory disorder, and causes of obesity are likely multifactorial. Hormonal imbalance, stress, fatigue, diet, and in particular, unhealthy gut microbiome can all play a role.  Not surprisingly, there has been little progress made in finding safe and effective pharmaceuticals to address this --- these drugs typically act on individual targets.

On the other hand, our herbal formula, MetaboCombo, is made of standardized and concentrated extracts from five herbs, each of which is chosen for its unique property and function.  The selection and the carefully balanced proportion of these ingredients are based on the wisdom of traditional Chinese medicine, modern medical research and, most importantly, over 20 years of real world application in Boston area integrative clinics.

These herb concentrates, atractylodes root, lotus leaf, gardenia flower, coptis root, cinnomon bark, are chosen because numerous pharmacological and clinical studies have revealed their potential benefits on stress, low energy, food craving, metabolism, and gut microbiota. (We have provided some of the relevant references below if you are interested in exploring further.) Their relative doses have also been optimized. Over a decade of application has shown that MetaboCombo helps many people boost energy, reduce appetite, and better manage their weight.

Please be advised that regular exercise and healthy lifestyle are the foundation of weight control. If you cannot achieve expected results after taking MetaboCombo for three months, we suggest that you stop taking this supplement or consult with your healthcare provider.

To make MetaboCombo, we have carefully chosen these well studied herbal extracts.  See below for some exciting research around these herbs.

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Coptis Extract (containing 60% Berberine, the optimal amount based on our study)


Berberine is a key ingredient of Coptis, which is also known as goldthread and has a long history of use in ethnic medicines. In recent years it has been a focus area in herbal medicine research and has the potential to become one of the most important herbal supplement in the world.


A large body of research data is showing its effect in promoting overall wellness in many areas. For examle, a new review by Dr. Francesco Di Pierro (see reference below) on the benefits of berberine summarizes that berberine’s influence on the gut microbiome accounts for much of its health benefit, which includes promoting weight loss, lowering blood lipids and blood pressure, and improving blood sugar control. We have chosen berberine not only because of it's been a key herb for thousands of years, but also because it’s become an important part of our answer to improving health via modulating the microbiota.

Impact of berberine on human gut bacteria. Di Pierro F. Nutrafoods (2018) 17:5-8.

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway.  Liu DZhang YLiu YHou LLi STian HZhao TExp Clin Endocrinol Diabetes. 2018 Sep;126(8):513-520. doi: 10.1055/s-0043-125066. Epub 2018 Jan 24.

Atractylodes (10:1 Concentrate)
Atractylodes is a genus of Asian flowering plants in the sunflower family. Increasingly more research data suggest the anti-inflammatory and anti-obesity activities of Atractylodis. Its rhizome was found to improve and adjust unhealthy gut flora (see reference below). In another study, astractylodes, fermented or not, exhibits marked anti-inflammatory, anti-adipogenic, and anti-obesity activities, as well as modulating the gut microbial distribution.

The Metabolism of Polysaccharide from Atractylodes macrocephala Koidz and Its Effect on Intestinal Microflora.  R. WangG. ZhouM. WangY. Peng, and X. Li  Evid Based Complement Alternat Med. 2014; 2014: 926381.

Fermented Rhizoma Atractylodis Macrocephalae alleviates high fat diet-induced obesity in association with regulation of intestinal permeability and microbiota in rats.  Jing-Hua Wang, Shambhunath Bose, +2 authors Hojun Kim Scientific Reports 2015


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